Dogs » High liver enzymes seizures

Malone

This question is related to: Belle the Dog

Age:5
Gender:Female
Breed:Yorkshire terrier
Neutered:Yes
Weight:2.7k
Fed On:Prescpiption wet food
Kept:Inside

High liver enzymes seizures

Belle is 5yr, she has been having seizure,since the age of 1. Belle has had high liver enzymes for the past 9 mths,she has had numerous test,liver biopsy normal ,scans,contrast x,ray,all appear to be normal ,she has been through so very much,but I am so scared, an answere will not be found,before it is too late,and she has liver failure,and dies. Her meds are ampicillin 1.5ml x3 daily,lactulose 1mlx3 daily,denamarin 1/4 tab daily.i don,t know if this would have any revalance,belle hurt herself,jumping from one chair to the other, she fell rather hard,this was 1yr ago could op for liver biopsy,or scan,have missed any damage,and if this was possible,is there a chance,her liver will recover,I am at my wits end please can anyone advise,me to help belle.

15/1/13

Answer this question
stuart

ok lets take the questions in reverse order. Yes it is possible for the liver to repair and regenerate. The liver does not recover from chronic alcohol induced cirrhosis (and she ain't likely to be affected by that!) but it can recover from most other conditions.
yes it is also possible for a localised liver condition to be missed on a needle biopsy especially if the scans are normal and thereby no guide as to which areas of liver to target.
is she on medication for the fitting? it is unlikely that the fits are caused by liver malfunction as if they were she would be unlikely to survive 4 years.
Have you discussed referral or a second opinion with your vet? I suspect that it may be welcomed by all concerned.

15/1/13

Malone

Belle had a op for suspected liver shunt,but no shunt was found,and a section of her liver was taken,she also had a contrast X-ray done at the same time,both normal,she has also had scans of her abdominal organs all appear within normal,only her bile acid test remain very high,the op and test were,all done by specialists,in a small animal hospital,but still no answere as to why her liver bile acids ar so high,could belle still recover,even when her bile acids,have hige for a period of 9mths.i am so worried for her,I just don't know what else to do,she is on ampicillin,lactulose,denamarin,but as yet these don't appear to be making her feel better,in fact I think the ampicillin,and possibily lactulose,is ,putting her of her food,

16/1/13

stuart

Finding hepato-portal shunts is a very very specialist task and not one that I would even consider especially in a little dog when there may well be several microshunts within the liver itself. is her fasting level also elevated? and what diet is she on ?
I would not consider changing the medication at all at this stage

16/1/13

Malone

Belle is on ,specific digestive support food,and bottled water,it was a specialist surgeon how operated,on and a small animal internal medicine specialist,that performed,ultrasound,contrast radiogram which was done at same time has time as op,no shunts were found,could there be another reason for bile acid test of total bilirubin,1.5 bile acid fasting 3.3, bile acid post fatty meal 119.9. Belle had a fall 1 yr ago, belle bile acids were noticed to be high 9mth ago could this be the I am so sorry to keep bothering you but I am so worried for belle,she is a special little dog who is loved so very much

17/1/13

stuart

cant see how the fall could be responsible for the dramatic bile acid increase after feeding. Either the liver has to be being paertially byepassed as in the hepato-portal shunt or there has to be a serious functional defect in the gall bladder preventing emptying and i feel sure that that would cause other changes within the liver and cause a rise in other liver enzymes and the total bilirubin. I feel sure that there has to be micro-shunts too small to show on ultrasound and effectively within the liver tissue so invisible. I would be interested to know what happens to the bile acids after a normal (liver support diet) meal and also how long the grossly elevated levels take to settle to normal. Assuming that the decimal points are in the right places the fasting e levels are very low and the after food levels amazingly high. What are her normal resting levels? do you have any details of her litter mates or other 'family' members?

17/1/13

Malone

I do not know what her,normal resting levels are,and the decimal point is in the right place according,to the test result,of which I have a copy,her other levels that are high,are ggt10u/l. 0-7 , lipa2505 u/l. 200-1800i also have the biopsy report and the scan report,when speaking to the specialist surgeon who performed her op she was of the opinion that belle didn't have a shunt or mvd,that was in June 2012 ,and that her liver blood work might go down,but her bile acids remained high taken 14.11.13. Thank you for taking the time to answere me.

17/1/13

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